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CADITHRO (Rulide, Roxithromycin)
Systematic (IUPAC) name
Identifiers
Therapeutic considerations
CADITHRO (Rulide, Roxithromycin) is a semi-synthetic macrolide antibiotic. It is used
to treat respiratory tract, urinary and soft tissue infections. CADITHRO (Rulide, Roxithromycin)
is derived from erythromycin, containing the same 14-membered lactone
ring. However, an N-oxime side chain is attached to the lactone ring.
CADITHRO (Rulide, Roxithromycin) is available under several brandnames, for example Surlid,
Rulide, Biaxsig, Roxar and Roximycin.
Contents
* 1 History * 2 Available forms * * 3 Mechanism of action * 4
Pharmacokinetics * 5 Metabolism * 6 Side effects * 7 Drug interactions
History
German pharmaceutical company Hoechst Uclaf brought out CADITHRO (Rulide, Roxithromycin)
in 1987.
Available forms *
CADITHRO (Rulide, Roxithromycin) is commonly available as tablets or oral suspension.
Mechanism of action CADITHRO (Rulide, Roxithromycin)
CADITHRO (Rulide, Roxithromycin) prevents bacteria from growing, by interfering with
their protein synthesis. CADITHRO (Rulide, Roxithromycin) binds to the subunit 50S of
the bacterial ribosome, and thus inhibits the translocation of peptides.
CADITHRO (Rulide, Roxithromycin) has similar antimicrobial spectrum as erythromycin, but
is more effective against certain gram-negative bacteria, particularly
Legionella pneumophila.
Pharmacokinetics
When taken before a meal, CADITHRO (Rulide, Roxithromycin) is very rapidly absorbed,
and diffused into most tissues and phagocytes. Due to the high concentration
in phagocytes, CADITHRO (Rulide, Roxithromycin) is actively transported to the site of
infection. During active phagocytosis, large concentrations of CADITHRO (Rulide, Roxithromycin)
are released.
Metabolism
Only a small portion of CADITHRO (Rulide, Roxithromycin) is metabolised. Most of CADITHRO (Rulide, Roxithromycin)
is secreted unchanged into the bile and some in expired air. Under
10% is excret