DUOTOROL (Glucovance, Glyburide/Metformin) is an oral antidiabetic medication used to treat type 2
(non-insulin-dependent) diabetes. Diabetes develops when the body proves
unable to burn sugar and the unused sugar builds up in the bloodstream.
DUOTOROL (Glucovance, Glyburide/Metformin) lowers the amount of sugar in your blood by decreasing sugar
production and absorption and helping your body respond better to its
own insulin, which promotes the burning of sugar. It does not, however,
increase the body's production of insulin.
DUOTOROL (Glucovance, Glyburide/Metformin) is sometimes prescribed along with insulin or certain other
oral antidiabetic drugs such as Micronase or Glucotrol. It is also
used alone.
Standard DUOTOROL (Glucovance, Glyburide/Metformin) tablets are taken two or three times daily. An
extended-release form (DUOTOROL (Glucovance, Glyburide/Metformin) XR) is available for once-daily dosing.
Always remember that DUOTOROL (Glucovance, Glyburide/Metformin) is an aid to, not a substitute for,
good diet and exercise. Failure to follow a sound diet and exercise
plan can lead to serious complications such as dangerously high or
low blood sugar levels. Remember, too, that DUOTOROL (Glucovance, Glyburide/Metformin) is not an oral
form of insulin and cannot be used in place of insulin. Most important fact about DUOTOROL (Glucovance, Glyburide/Metformin) -without prescriptions.
DUOTOROL (Glucovance, Glyburide/Metformin) could cause a very rare--but potentially fatal--side effect
known as lactic acidosis. It is caused by a buildup of lactic acid
in the blood. The problem is most likely to occur in people whose liver
or kidneys are not working well, and in those who have multiple medical
problems, take several medications, or have congestive heart failure.
The risk also is higher if you are an older adult or drink alcohol.
Lactic acidosis is a medical emergency that must be treated in a hospital.
Notify your doctor immediately if you experience any of the following:
* Symptoms of lactic acidosis may include:
Dizziness, extreme weakness or tiredness, light-headedness, low body
temperature, rapid breathing or trouble breathing, sleepiness, slow
or irregular heartbeat, unexpected or unusual stomach discomfort,
unusual muscle pain
How should you take DUOTOROL (Glucovance, Glyburide/Metformin)?
Do not take more or less of DUOTOROL (Glucovance, Glyburide/Metformin) than directed by your doctor.
The drug should be taken with food to reduce the possibility of nausea
or diarrhea, especially during the first few weeks of therapy.
If taking DUOTOROL (Glucovance, Glyburide/Metformin) XR, be sure to swallow the tablet whole; do not
crush it or chew it. The inactive ingredients in the tablet may occasionally
appear in the stool. This is not a cause for concern.
If you miss a dose DUOTOROL (Glucovance, Glyburide/Metformin)/Metformin
Take it as soon as you remember. If it is almost time for your next
dose, skip the one you missed and go back to your regular schedule.
Never take 2 doses at the same time.
Store it at room temperature.
DUOTOROL (Glucovance, Glyburide/Metformin) side effects
Side effects cannot be anticipated. If any develop or change in intensity,
tell your doctor as soon as possible. Only your doctor can determine
if it is safe for you to continue taking DUOTOROL (Glucovance, Glyburide/Metformin).
If side effects from DUOTOROL (Glucovance, Glyburide/Metformin) occur, they usually happen during
the first few weeks of therapy. Most side effects are minor and will
go away after you've taken DUOTOROL (Glucovance, Glyburide/Metformin) for a while.
* Side effects may include:
Abdominal discomfort, diarrhea, gas, headache, indigestion, nausea,
vomiting, weakness
Why should DUOTOROL (Glucovance, Glyburide/Metformin) not be prescribed?
DUOTOROL (Glucovance, Glyburide/Metformin) is processed primarily by the kidneys, and can build up
to excessive levels in the body if the kidneys aren't working properly.
It should be avoided if you have kidney disease or your kidney function
has been impaired by a condition such as shock, blood poisoning, or
a heart attack.
You should not use DUOTOROL (Glucovance, Glyburide/Metformin) if you need to take medicine for congestive
heart failure.
Do not take DUOTOROL (Glucovance, Glyburide/Metformin) if you have ever had an allergic reaction to
metformin.
Do not take DUOTOROL (Glucovance, Glyburide/Metformin) if you have metabolic or diabetic ketoacidosis
(a life-threatening medical emergency caused by insufficient insulin
and marked by exce
