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ONOTREX (Methotrexate) is an anticancer drug used in the treatment of lymphoma
(cancer of the lymph nodes) and certain forms of leukemia. It is also
given to treat some forms of cancers of the uterus, breast, lung, head,
neck, and ovary. ONOTREX (Methotrexate) is also given to treat rheumatoid arthritis
when other treatments have proved ineffective, and is sometimes used
to treat very severe and disabling psoriasis (a skin disease characterized
by thickened patches of red, inflamed skin often covered by silver
scales).
Most important fact about ONOTREX (Methotrexate)
Be certain to remember that in the treatment of psoriasis and rheumatoid
arthritis, ONOTREX (Methotrexate) is taken once a week, not once a day. Accidentally
taking the recommended weekly dosage on a daily basis can lead to fatal
overdosage. Be sure to read the patient instructions that come with
the package. How should you take ONOTREX (Methotrexate)?
Take ONOTREX (Methotrexate) exactly as prescribed, and promptly report to your
doctor any new symptoms that may develop.
ONOTREX (Methotrexate) is given at a higher dosage for cancer than for psoriasis
or rheumatoid arthritis. After high-dose ONOTREX (Methotrexate) treatment, a
drug called leucovorin may be given to limit the toxic effects.
If you miss a dose...
Skip it and go back to your regular schedule. Do not take 2 doses
at once.
Storage instructions...
Store at room temperature, away from light. ONOTREX (Methotrexate) side effects
Side effects cannot be anticipated. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can determine
whether it is safe for you to continue taking ONOTREX (Methotrexate).
* Side effects may include:
Abdominal pain and upset, chills and fever, decreased resistance to infection,
dizziness, fatigue, general feeling of illness, mouth ulcers, nausea
If you are taking ONOTREX (Methotrexate) for psoriasis, you may also experience
hair loss and/or sun sensitivity, and your patches of psoriasis may
give a burning sensation.
ONOTREX (Methotrexate) can sometimes cause serious lung damage that makes it
necessary to limit the treatment. If you experience a dry cough, fever,
or breathing difficulties while taking ONOTREX (Methotrexate), be sure to tell
your doctor right away.
During and immediately after treatment with ONOTREX (Methotrexate), fertility
may be impaired. Men may have an abnormally low sperm count; women
may have menstrual irregularities.
People on high doses of ONOTREX (Methotrexate) may develop a brain condition
signaled by confusion, partial paralysis, seizures, or coma. Why should ONOTREX (Methotrexate) not be prescribed?
Do not take ONOTREX (Methotrexate) if you are sensitive to it or it has given
you an allergic reaction.
Do not take ONOTREX (Methotrexate) if you are pregnant.
ONOTREX (Methotrexate) treatment is not suitable for you if you suffer from
psoriasis or rheumatoid arthritis and also have one of the following
conditions:
Abnormal blood cell count
Alcoholic liver disease or other chronic liver disease
Alcoholism
Anemia
Immune-system deficiency Special warnings about ONOTREX (Methotrexate)
Before you start taking ONOTREX (Methotrexate), your doctor will do a chest
X-ray plus blood tests to determine your blood cell counts, liver enzyme
levels, and the efficiency of your kidney function. While you are taking
ONOTREX (Methotrexate), the blood tests will be repeated at regular intervals;
if you develop a cough or chest pain, the chest X-ray will be repeated.
If you are being treated for psoriasis or rheumatoid arthritis, your
doctor will test your liver function at regular intervals. You should
avoid alcoholic beverages while taking ONOTREX (Methotrexate).
You may develop an opportunistic infection--one that takes advantage
of your altered body chemistry--while you are taking ONOTREX (Methotrexate).
Before receiving an immunization or vaccination, be sure to inform
