Brand name: Brand name:
MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)
Pronounced: TEG-re-tawl
Generic name: Carbamazepine
Other brand names: Carbatrol, Epitol, MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)-XR
Why is MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) prescribed?

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) is used in the treatment of seizure disorders, including certain types of epilepsy. It is also prescribed for trigeminal neuralgia (severe pain in the jaws) and pain in the tongue and throat.

In addition, some doctors use MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) to treat alcohol withdrawal, cocaine addiction, and emotional disorders such as depression and abnormally aggressive behavior. The drug is also used to treat migraine headache and "restless legs."
Most important fact about MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)

There are potentially dangerous side effects associated with the use of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol). If you experience symptoms such as fever, sore throat, rash, ulcers in the mouth, easy bruising, or reddish or purplish spots on the skin, you should notify your doctor immediately. These symptoms could be signs of a blood disorder brought on by the drug.
How should you take MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)?

This medication should only be taken with meals, never on an empty stomach.

Shake the suspension well before using.

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)-XR (extended-release) tablets must be swallowed whole; do not crush or chew them and do not take tablets that have been damaged.

If you miss a dose MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)

Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once. If you miss more than 1 dose in a day, check with your doctor.

Storage instructions...

Store MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) at room temperature. Keep the container tightly closed. Protect the tablets from light and moisture. Keep the liquid suspension away from light.
MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) side effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol).

* Side effects especially at the start of treatment may include:
Dizziness, drowsiness, nausea, unsteadiness, vomiting

* Other side effects may include:
Allergic reactions, blood pressure changes, bone marrow suppression, hives, rash, sensitivity to light, swelling

Why should MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) not be prescribed?

You should not use MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) if you have a history of bone marrow depression (reduced function), a sensitivity to MEZARIL (Atretol, Carbamazepine,Depitol,Epitol), or a sensitivity to tricyclic antidepressant drugs such as amitriptyline (Elavil). You should also not be taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) if you are on an MAO inhibitor antidepressant such as Nardil or Parnate, or if you have taken such a drug within the past 14 days.

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) is not a simple pain reliever and should not be used for the relief of minor aches and pains.
Special warnings about MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)

If you have a history of heart, liver, or kidney damage, an adverse blood reaction to any drug, glaucoma, or serious reactions to other drugs, you should discuss this history thoroughly with your doctor before taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol).

Anticonvulsant drugs such as MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) should not be stopped abruptly if you are taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) to prevent major seizures. There exists the strong possibility of continuous epileptic attacks without return to consciousness, leading to possible severe brain damage and death. Only your doctor should determine if and when you should stop taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol).

Since dizziness and drowsiness may occur while taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol), you should refrain from operating machinery or driving an automobile or participating in any high-risk activity that requires full mental alertness until you know how MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) affects you.

Older adults, especially, can become confused or agitated when taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol).

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) has been known to cause serious blood, liver, and skin reactions, both early in treatment and after extended use. Alert your doctor immediately if you develop such warning signs as fever, sore throat, rash, ulcers in the mouth, easy bruising or spots in the skin, swollen lymph glands, loss of appetite, nausea or vomiting, or yellowing of the skin and eyes.

The coating of the MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)-XR tablet is not absorbed and passes through your body intact. If you notice it in your stool, it is not a cause for alarm.
Possible food and drug interactions when taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)

The use of the antiseizure medications phenobarbital, phenytoin (Dilantin), or primidone (Mysoline) may reduce the effectiveness of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol). Take other anticonvulsants along with MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) only if your doctor advises it. The use of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) with other anticonvulsants may change thyroid gland function.

All of the following drugs may raise the amount of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) in the blood to harmful levels:

Azithromycin (Zithromax)
Calcium channel blockers such as Calan, Plendil, Sular, and Procardia
Cimetidine (Tagamet)
Clarithromycin (Biaxin)
Danazol (Danocrine)
Diltiazem (Cardizem)
Erythromycin (E-Mycin)
Fluoxetine (Prozac)
Isoniazid (Nydrazid)
Itraconazole (Sporanox)
Ketoconazole (Nizoral)
Loratadine (Claritin)
Niacinamide
Nicotinamide
Propoxyphene (Darvon)
Troleandomycin (Tao)
Valproate (Depakene, Depakote)

The following drugs may also reduce the effectiveness of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol):

Cisplatin (Platinol)
Doxorubicin HCl (Adriamycin)
Felbamate (Felbatol)
Rifampin (Rifadin, Rimactane)
Theophylline (Theo-24, Uniphyl)

When taken with MEZARIL (Atretol, Carbamazepine,Depitol,Epitol), the effectiveness of the following drugs may be reduced:

acetaminophen, alprazolam, calcium channel blockers (such as Plendil and Sular), clonazepam, clozapine, corticosteroids such as Pediapred and Decadron, cyclosporine, dicumarol, doxycycline, ethosuximide, haloperidol, itraconazole, lamotrigine, levothyroxine, methadone, methsuximide, midazolam, olanzapine, oral contraceptives, oxcarbazepine, phensuximide, phenytoin, praziquantel, protease inhibitors (such as Crixivan, Norvir, and Viracept), risperidone, theophylline, tiagabine, topiramate, tramadol, tricyclic antidepressants (such as Elavil, Pamelor, and Tofranil), valproic acid, warfarin, ziprasidone, and zonisamide.

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) may increase the effectiveness of clomipramine HCl (Anafranil), phenytoin, or primidone if the drugs are taken together.

Lithium (Eskalith) used with MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) may cause harmful nervous system side effects.

If you are taking an oral contraceptive and MEZARIL (Atretol, Carbamazepine,Depitol,Epitol), you may experience blood spotting and your contraceptive may not be completely reliable.

Do not combine MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) suspension with other liquid medications such as Thorazine solution or Mellaril liquid. The mixture may congeal internally.
Special information if you are pregnant or breastfeeding

There are no adequate safety studies regarding the use of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) in pregnant women. However, there have been reports of birth defects in infants. Therefore, MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) should be used during pregnancy only if the potential benefits justify the potential risk to the fetus. If you are pregnant or plan on becoming pregnant, you should discuss this with your doctor.

MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) appears in breast milk. If you are breastfeeding, your doctor may advise you to discontinue doing so if taking MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) is essential to your health.
Recommended dosage for MEZARIL (Atretol, Carbamazepine,Depitol,Epitol)

ADULTS
Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately. The first signs and symptoms of an overdose of MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) appear after 1 to 3 hours.

* The most prominent signs of a MEZARIL (Atretol, Carbamazepine,Depitol,Epitol) overdose include:
Coma, convulsions, dizziness, drowsiness, inability to urinate, involuntary rapid eye movements, irregular or reduced breathing, absence or low production of urine, lack of coordination, low or high blood pressure, muscular twitching, nausea, pupil dilation, rapid heartbeat, restlessness, severe muscle spasm, shock, tremors, unconsciousness, vomiting, writhing movements