Name of brand : UROTONE (Bethanechol Chloride, Duvoid, Myotonachol, Urecholine)
Name of generic : Bethanechol Chloride Duvoid Myotonachol Urecholine
Available dose&quan : 25mg Tabs 100 (10 x 10)
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Short descriptions : Bethanechol is used to relieve difficulties in urinating caused by surgery, drugs, or other factors.Bethanechol comes as a tablet to take by mouth. Bethanechol usually is taken two to four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take bethanechol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.Bethanechol usually is taken at evenly relieve difficulties in urinating caused by surgery, drugs, or other factors.
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Brand
name : UROTONE (Bethanechol Chloride, Duvoid, Myotonachol, Urecholine)
DESCRIPTION Bethanechol Chloride is a choline ester quaternary ammonium salt. As
a parasympathomimetic agent, it has little nicotinic activity and its
actions are predominantly muscarinic actions of acetyl choline. Since
it is not hydrolysed by choline esterases, its actions are more prolonged
than those of acetyl choline. It is used as an alternative to catheterisation
in the treatment of urinary retention.
INDICATIONS
Nonobstructive urinary retention and retention due to neurogenic bladder;
treatment and prevention of bladder dysfunction caused by phenothiazines;
diagnosis of flaccid or atonic neurogenic bladder; gastroesophageal
reflux.
Pregnancy Risk Factor C
CONTRAINDICATIONS
Hypersensitivity to bethanechol; do not use in patients with mechanical
obstruction of the GI or GU tract or when the strength or integrity
of the GI or bladder wall is in question. It is also contraindicated
in patients with hyperthyroidism, peptic ulcer disease, epilepsy, obstructive
pulmonary disease, bradycardia, vasomotor instability, atrioventricular
conduction defects, hypotension, or parkinsonism; contraindicated for
I.M. or I.V. use due to a likely severe cholinergic reaction.
WARNINGS/PRECAUTIONS
Potential for reflux infection if the sphincter fails to relax as bethanechol
contracts the bladder; use with caution when administering to nursing
women, as it is unknown if the drug is excreted in breast milk; safety
and efficacy in children <5 years of age have not been established;
syringe containing atropine should be readily available for treatment
of serious side effects.
DRUG INTERACTIONS
Decreased effect: Procainamide, quinidine Increased toxicity: Bethanechol
and ganglionic blockers ® critical fall in blood pressure; cholinergic
drugs or anticholinesterase agents
OVERDOSAGE/TOXICOLOGY
Symptoms of overdose include nausea, vomiting, abdominal cramps, diarrhea,
involuntary defecation, flushed skin, hypotension, bronchospasm Atropine
is the treatment of choice for intoxications manifesting with significant
muscarinic symptoms; atropine I.V. 0.6 mg every 3-60 minutes (or
0.01 mg/kg I.V. every 2 hours if needed for children) should be repeated
to control symptoms and then continued as needed for 1-2 days following
the acute ingestion. Epinephrine 0.1-1 mg S.C. may be useful in reversing
severe cardiovascular or pulmonary sequel.
MECHANISM OF ACTION
Stimulates cholinergic receptors in the smooth muscle of the urinary
bladder and gastrointestinal tract resulting in increased peristalsis,
increased GI and pancreatic secretions, bladder muscle contraction,
and increased ureteral peristaltic waves
PHARMACODYNAMICS/KINETICS Onset of action: Oral: 30-90 minutes
S.C.: 5-15 minutes
Duration of action:
Oral: Up to 6 hours
S.C.: 2 hours
Absorption: Oral: Variable .
USUAL DOSAGE I.V.
Children: Oral: Abdominal distention or urinary retention: 0.6 mg/kg/day divided
3-4 times/day Gastroesophageal reflux: 0.1-0.2 mg/kg/dose given 30
minutes to 1 hour before each meal to a maximum of 4 times/day
S.C.: 0.15-0.2 mg/kg/day divided 3-4 times/day
Adults:
Oral: 10-50 mg 2-4 times/day S.C.: 2.5-5 mg 3-4 times/day, up to 7.5-10
mg every 4 hours for neurogenic bladder
PATIENT INFORMATION Oral should be taken 1 hour before meals or 2 hours after meals to
avoid nausea or vomiting; may cause abdominal discomfort, salivation,
sweating or flushing - notify physician if these symptoms become
pronounced; rise slowly from sitting/lying down.
How to buy Urotone
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